2,7-BIS(TRICHLOROMETHYL)-1,8-NAPHTHYRIDINETHIS PAPER IS DEDICATED TO HIS MAJESTY KING BHUMIBOL ADULYADEJ OF THAILAND (KING RAMA IX) FOR HIS SUSTAINABLE DEVELOPMENT OF THE COUNTRY.

The complete molecule of the title compound, 310.32.42.50.01.001 C10H4Cl6N2, is generated by crystallographic twofold symmetry, with two C atoms lying on the rotation axis; the 1,8-naphthyridine ring is almost planar with an r.m.s.deviation of 0.0002 Å.In the crystal structure, the molecules are stacked in an antiparallel manner

The evolution of transcriptional regulators through the recruitment of DNA-binding domains by enzymes is a widely held notion.However, few experimental approaches have directly addressed this hypothesis.Here we report the reconstruction of a plausible pathway for the evolution of an enzyme into a transcriptional regulator.The BzdR protein is the pr

For many decades, Hemoglobin-based oxygen carriers (HBOCs) have been central in the development of resuscitation agents that might provide oxygen delivery in addition to simple volume expansion.Since 80% of the world population lives in areas where fresh blood products are tumbler lid that holds liquor not available, the application of these new so